Publications From IITB
In 2025
26. Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of
mammalian cells. Charan, K. and Kar, S. iScience 2025
In 2024
25. Interlinked bi-stable switches govern the cell fate commitment of embryonic stem cells
A. Giri and S. Kar, FEBS Letters 2024
https://doi.org/10.1002/1873-3468.14832
In 2023
24. Deciphering the impact of pulsatile input in the population-level synchrony of the Hes1 oscillators
A. Giri and S. Kar, J. Chem. Sci. 2023 (Special Issue on Interplay of Structure and Dynamics in Reaction Pathways, Chemical Reactivity and Biological Systems)
https://link.springer.com/article/10.1007/s12039-023-02177-y
In 2022
23. Transcriptional fluctuations govern the serum dependent cell cycle duration heterogeneities in Mammalian cells
G. Vinodhini, S. Sarma, S. Karulkar, R. Purwar and S. Kar ACS Synthetic Biology 2022
https://pubs.acs.org/doi/10.1021/acssynbio.2c00347
22. Elucidating the Implications of Diverse Dynamical Responses in p53 Protein
K. Charan*, A Giri* and S. Kar ChemPhysChem 2022
(* Equal contribution 1st author)
https://doi.org/10.1002/cphc.202200537
21. Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response
S. Biswas*, B. Tikader*, S. Kar and G. A. Viswanathan PLOS COMPUTATIONAL BIOLOGY 2022
(* Equal contribution 1st author)
https://doi.org/10.1371/journal.pcbi.1010626
20. Intrinsic Elasticity of a Three-Dimensional Macroporous Scaffold Governs the Kinetics of In Situ Biomimetic Reactions
L. Hegde*, B. Tikader*, A. Srivatsav, S. Kar and K. Sharma
(* Equal contribution 1st author) Chem. Mater. 2022,
In 2021
19. Unraveling the origin of glucose mediated disparate proliferation dynamics of cancer stem cells
T. Samanta and S. Kar, J. Theo. Biol., 526, 110774, (2021).
https://doi.org/10.1016/j.jtbi.2021.110774
18. Role of microRNAs in oncogenesis: Insights from computational and systems-level modeling approaches
G. Vinodhini and S. Kar, Comput Syst Oncol., 1:e1028. (2021;).
https://doi.org/10.1002/cso2.1028
17. Deciphering the Role of Fluctuation Dependent Intercellular Communication in Neural Stem Cell Development
A. Giri, D. Sengupta and S. Kar, ACS Chemical Neuroscience, 12, 2360-2372, (2021).
https://doi.org/10.1021/acschemneuro.1c00116
16. Incoherent modulation of bi-stable dynamics orchestrates the Mushroom and Isola bifurcations
A. Giri and S. Kar, J. Theo. Biol., 530, 110882, (2021).
https://doi.org/10.1016/j.jtbi.2021.110882
15. A generic approach to decipher the mechanistic pathway of heterogeneous protein aggregation kinetics
B. Tikader, S. K. Maji and S. Kar, Chem. Sci., 12, 13530, (2021).
In 2020
14. Fine-tuning Nanog expression heterogeneity in embryonic stem cells by regulating a Nanog transcript- specific microRNA
T. Samanta and S. Kar, FEBS Letters, 594, 4292-4306, (2020). '
https://doi.org/10.1002/1873-3468.13936
13. Alteration in cross diffusivities governs the nature and dynamics of spatiotemporal pattern formation
A. Giri, S. Jain, and S. Kar, Chem. Phys. Chem., 21, 1608-1616, (2020).
In 2019
12. Investigating the effect of circularly polarized electric field on spatially extended Gray-Scott model
A. Giri and S. Kar, J. Indian Chem. Soc., 96, 809-816, (2019).
(Special issue of JICS on "Theoretical and Computational Chemistry", Edited by Prof. P. K. Chattaraj)
https://doi.org/10.5281/zenodo.5644586
11. Dynamical reorganization of transcriptional events governs robust Nanog heterogeneity
T. Samanta and S. Kar, J. Phys. Chem. B, 123, 5246-5255, (2019).
https://doi.org/10.1021/acs.jpcb.9b03411
10. Unraveling the diverse nature of electric field induced spatial pattern formation in Gray-Scott model
A. Giri and S. Kar, Journal of Chemical Physics, 150, 094904-11, (2019).
In 2018
9. Disproportionate feedback interaction govern cell-type specific proliferation in mammalian cells
D. Sengupta*, V. P. S. Kompella* and S. Kar, FEBS Letters, 592, 3248-3263, (2018).
https://doi.org/10.1002/1873-3468.13241
8. Alteration in microRNA-17-92 dynamics accounts for differential nature of cellular proliferation
D. Sengupta*, G. Vinodhini* and S. Kar, FEBS Letters, 592, 446-458, (2018).
https://doi.org/10.1002/1873-3468.12974 (* Equal contribution 1st author)
7. Deciphering the dynamical origin of mixed population during neural stem cell development
D. Sengupta and S. Kar, Biophysical Journal, 114, 992-1004, (2018).
DOI: https://doi.org/10.1016/j.bpj.2017.12.035
In 2017
6. Alteration in microRNA expression governs the nature and timing of cellular fate commitment
D. Sengupta and S. Kar, ACS Chemical Neuroscience, 9(4), 725-737, (2018).
DOI: https://doi.org/10.1021/acschemneuro.7b00423
5. Decoding the regulatory mechanism of Glucose and Insulin induced Phosphatidyinositol 3,4,5- Trisphosphate
dynamics in β-cells
T. Samanta*, P. Sharma*, D. Kukri and S. Kar, Molecular BioSystems, 13, 1512-1523, (2017).
DOI: https://doi.org/10.1039/C7MB00227K (* Equal contribution 1st author)
4. Protein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation
L. Adlung*, S. Kar*, M. C. Wagner*, B. She*, S. Chakraborty, J. Bao, S. Lattermann, M. Boerries, H. Busch, J.
Timmer, M. Schilling, T. Hoefer and U. Klingmueller. Molecular Systems Biology, 13: 904 (2017).
DOI: https://doi.org/10.15252/msb.20167258 (* Equal contribution 1st author)
In 2016
3. Unraveling the differential dynamics of developmental fate in central and peripheral nervous system
D. Sengupta and S. Kar, Scientific Reports, 6: 36397, (2016).
DOI: https://doi.org/10.1038/srep36397
2. Unraveling Cell-Cycle Dynamics in Cancer
S. Kar, Cell Systems, 2: 8, (2016).
http://dx.doi.org/10.1016/j.cels.2016.01.007 (Preview article)
In 2015
1. Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?
D. Sengupta and S. Kar, Plos One, 10(9): e0136668, (2015).
Representative Publications before joining IITB
1. Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration
R. Meyer★, L. A. D`Alessandro★, S. Kar★, B. Kramer, S. Bin, D. Kaschek, B. Hahn, D. Wrangborg, J. Karlsson,
M. Kvarnstrom, M. Jirstrand, W. D. Lehmann, J. Timmer, T. Höfer and U. Klingmüller, Frontiers in Physiology,
doi: 10.3389/fphys.2012.00451 (2012). (★ Equal contribution 1st author)https://doi.org/10.3389/fphys.2012.0045
2. Exploring the Roles of Noise in the Eukaryotic Cell Cycle S. Kar, W. Baumann, M. R. Paul and J. J. Tyson, Proc. Natl. Acad. Sci., 106, 6471, (2009).https://doi.org/10.1073/pnas.0810034106
3. Sustained simultaneous Glycolytic and Insulin oscillations in β-cells
S. Kar and D.S. Ray, J. Theo. Biol., 237, 58, (2005). 10.1016/j.jtbi.2005.03.031
4. Collapse and Revival of Glycolytic oscillation
S. Kar and D.S. Ray, Physical Review Letters, 90, 238102, (2003).https://doi.org/10.1103/PhysRevLett.90.238102